Abstract
The concentration of glucose and glycosylated hemoglobin in the blood of animals increases as a result of physiological aging. This is due to damage to the pancreatic insular apparatus and a decrease in the number and functioning of active β-cells. The development of alloxan-induced diabetes in old rats is characterized by a decrease in the number of islets of Langerhans, an enlargement of the preserved islets, and a sharp decrease in the number of active endocrine cells. The injection of lipoic acid partially corrected the morphofunctional condition of the islets of Langerhans and the biochemical values of the animals’ peripheral blood.
Highlights
Diabetes attracts the attention of gerontologists as an age-dependent disease that shortens lifespan and modulates the basic aging mechanisms [1]
The aim of this study is to identify the features of compensatory reactions of pancreatic insular apparatus in old animals in alloxan-induced diabetes and its correction using lipoic acid
Our results indicate successful joint correction of hyperglycemia, the accumulation of glycated blood proteins and the product of malondialdehyde lipid peroxidation under the influence of lipoic acid
Summary
Diabetes attracts the attention of gerontologists as an age-dependent disease that shortens lifespan and modulates the basic aging mechanisms [1]. It is a well-known fact that the incidence of diabetes increases with age [2]. Lipoic acid (a natural antioxidant, anti-glycation agent, and geroprotector) is of special attention among the known methods for the pathogenetic correction of experimental diabetes in old animals [3, 7, 8]. Age-related features of the lipoic acid have not yet been sufficiently studied
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