Abstract
Aim. To study the effect of magnesium orotate, magnesium/pyridoxine combination and magnesium sulfate on fibroblast morphofunctional characteristics in cell culture of fibroblasts (McCoy line). Material and methods. The study of fibroblasts (McCoy line) with the addition of magnesium-containing preparations (magnesium orotate, magnesium/pyridoxine combination, magnesium sulphate) to the culture medium was performed using scanning and transmission electron microscopy. Results. When adding into the media magnesium orotate or magnesium/pyridoxine combination, significant changes in morphofunctional state of fibroblasts were noted, which were absent when adding magnesium sulfate. At that fibroblasts significantly promoted synthetic and secretory activity. This was expressed in the formation of amorphous and fibrous components in well-formed cell layers. Conclusion. Stimulation by magnesium ions of the proliferative activity of fibroblasts is shown in the morphological analysis of the effect of magnesium orotate or magnesium in combination with pyridoxine and magnesium sulfate on morphological and functional organization of fibroblasts. Revealed the predominant influence of magnesium orotate, and a less pronounced effect of magnesium in combination with pyridoxine on biosynthetic processes in the cells, including the synthesis of amorphous and fibrous components (protocollagen and elastin) of the extracellular matrix founded.
Highlights
Магния в комбинации с пиридоксином
Summary
Магния в комбинации с пиридоксином, сульфата магния на морфофункциональные характеристики фибробластов клеточной культуры фибробластов линии McCoy. Материал и методы. Методами сканирующей и просвечивающей электронной микроскопии было проведено исследование культуры фибробластов клеточной линии McCoy при добавлении в среду культивирования магнийсодержащих препаратов (магния оротата, магния в комбинации с пиридоксином, сульфата магния). Aim. To study the effect of magnesium orotate, magnesium/pyridoxine combination and magnesium sulfate on fibroblast morphofunctional characteristics in cell culture of fibroblasts (McCoy line). Того же центра Кост Елена Андреевна – к.б.н., м.н.с. Того же центра Улубиева Елена Арсеновна – к.м.н., доцент кафедры терапии и подростковой медицины РМАПО Тимофеева Анна Вячеславовна – к.м.н., доцент той же кафедры Автандилов Александр Георгиевич – д.м.н., профессор, заведующий той же кафедрой ткани в значительной мере определяются структурнофункциональным статусом клеток фибробластического ряда [1].
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