Morphofunctional change small intestine in patients with ulcer disease

Abstract

The current course of diseases of the digestive system is characterized by a multi-system pathology. The long-term existence of isolated diseases of the organs of the gastrointestinal tract is impossible: the pathology of some organs of a single functional system affects the development of the pathology of other organs.Purpose. To study the features of intestinal digestion in patients with peptic ulcer.Material and methods. 152 patients with peptic ulcer who were hospitalized in the gastroenterological department of Mordovian Republican Clinical Hospital were examined in 2011–2017. The main indicators of intestinal digestion by the activity of intestinal enzymes were studied.Results. Symptoms of impaired intestinal function are observed in 47 % of patients with peptic ulcer disease. In their development, a violation of membrane hydrolytic processes, which were expressed as a decrease (p < 0.05) in the activity of the main intestinal enzymes of maltase in 74 %, alanine aminopeptidase – 73 %, alkaline phosphatase – 62 %, glycyl-L-leucindipeptidase and protein – 37 % (p < 0.01).Conclusions. With peptic ulcer, the processes of membrane intestinal digestion are disrupted, which contributes to the development of clinical symptoms of a violation of the basic functions of the small intestine.