MORPHO-FUNCTIONAL PROPERTIES OF ERYTHROCYTES AS A MARKER OF THE PROGRESS OF KIDNEY INJURIES IN PATIENTS WHO HAD CORONAVIRUS DISEASE

Abstract

Pathology of the morpho-functional state of erythrocytes affects the rheological properties of blood and various regulatory processes that ensure microcirculation in the kidneys. Changes in the morpho-functional state of erythrocytes are the cause of pathological effects on the membranes and receptors of kidney cells. It leads to adverse disorders of vital activity and functioning of the kidneys.Aim. The paper aims to investigate the morpho-functional state of erythrocytes in patients with kidney damage who were sick with COVID-19. Material and methods. 75 patients aged 45-65 years with kidney damage who suffered from moderate COVID 8-12 months ago were examined. Research groups and control groups were formed (patients with appropriate nosology who did not suffer from COVID): I – glomerulonephritis; II – pyelonephritis; ІІІ – diabetic nephropathy of the 4th century. All patients had a protocol examination of nephrological patients, and we also examined the morpho-functional properties of erythrocytes (the deformability index of erythrocytes, peroxide hemolysis of erythrocytes and the relative viscosity of the erythrocyte suspension using filtration methods.Results. Changes in the morpho-functional properties of erythrocytes may indicate the progressive course of kidney diseases in patients who have undergone COVID. It manifested by a decrease in the deformability index of erythrocytes, by more than 40% in patients with glomerulonephritis and twice in patients with diabetic nephropathy, as well as a probable increase in the relative viscosity of the erythrocyte suspension, which was 2 times higher in the group with glomerulonephritis and 3 times higher in the group with diabetic nephropathy compared with pyelonephritis. An inverse correlation between daily proteinuria and the index of deformability of erythrocytes in patients with chronic kidney disease (CKD) after COVID (r=-0.59) (р=0.041), as well as a direct correlation between peroxide hemolysis of erythrocytes and daily proteinuria (r=0.68) ( p=0.038) and between the relative viscosity of the erythrocyte suspension with daily proteinuria (r=0.76) (p=0.035) were detected.Conclusions. Changes in the morpho-functional properties of erythrocytes were more profound in patients with diabetic nephropathy and glomerulonephritis after experiencing COVID than in patients with pyelonephritis. A correlation was found between indicators of morpho-functional properties of erythrocytes and daily proteinuria. Indicators of the morpho-functional properties of erythrocytes can be markers of the progression of CKD in patients who have experienced moderate COVID.