Abstract
Autosomal Dominant Leukodystrophy (ADLD) is a rare and fatal adult-onset neurodegenerative disorder that affects the central nervous system. It is characterized by Lamin B1 (LMNB1) gene duplication or deletion upstream the gene, but the molecular mechanisms responsible for driving the onset and development of this pathology are not clear yet. Considering the pivotal role that glial cells as oligodendrocytes and astrocytes, and Leukemia Inhibitory Factor (LIF)-activated signaling pathways have in the myelination process, this work aims to analyze the specific alterations in different cell populations
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
