Abstract
Patients receiving opioids for pain may experience abnormal pain sensitivity – either hyperalgesia and/or allodynia. We hypothesize that peripheral sensory sensitization contributes to opioid-induced hyperalgesia, and test this using ex vivo mouse glabrous skin-nerve preparations. Adult male C57BL6 mice were injected intraperitoneally with escalating doses of morphine (5, 8, 10, and 15 mg/kg) or saline every 12h for 48h and sacrificed ≈12h following the last injection. Glabrous skin of the hindpaw with plantar nerve attached was dissected free and placed in a recording chamber superfused with artificial interstitial fluid.
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