Abstract
Evidence that action on peripheral opiate receptors is necessary to produce aversive effects with morphine, enabled us to determine whether preexpsoure to these aversive effects is necessary for the alter attenuation of morphine's aversive properties. We found that blockaced of the aversive effects of morphine with the peripheral antagonist methylnaltrexone during morphine preexposure had no effect on the later attenuated development of conditioned taste aversion to morphine. Moreover, in the same rat morphine preexposure did not affect the development of a place preference to an enviroment paired with injections of morphine. The results suggsest that an effect of central oppiate action is able to attenuate the later peripheral aversive, but not the central rewarding, effects of morphine.
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