Abstract
Morphine analgesia was examined in rats with the Formalin test, which produces moderate pain that lasts about 2 h, and with the tail-flick test which measures brief, threshold-level pain. Lesions of the nucleus raphe magnus and the caudal periaqueductal gray attenuate the effects of morphine in the tail-flick test but do not influence analgesia in the Formalin test. The results indicate that different neural mechanisms underlie the analgesic effects of morphine in different types of pain.
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