Abstract
Twenty-three Sprague-Dawley rats received 0, 60, and 45 or 75 μg of morphine in 0.5 μl of Ringer's solution in the region of the dorsal medullary nucleus tractus solitarius (NTS). Morphine produced naloxone-reversible analgesia (as measured by the tail-flick test) and catatonia, and non-naloxone-reversible barrel rolling, depending on cannula placement. The NTS region thus appears to participate in an opiate-sensitive pain-suppressive system.
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