Morning spot urine protein-creatinine ratio assent urine protein excretion and their clinical evaluation among CKD patients

Abstract

Objectives To evalute the clinical application of total protein-to-creatinine ratio in spot urine specimens as a predictor of urine protein exeretion among the CKD patients.Methods One hundred and thirty apecimens of 24-hour urine collection,first morning urine specimend from 136 impatients were collected.The correlations between Protein-to-creatinine ratio in first morning urine specimens and urinary protein excretion in 24-hour collections were analyzed.Influence about collections between p/c and tpu of factors such as GFR、sex、age and BMI were analyzed.The cutoff values of Protein-to-creatinine ratio in first morning urine specimens for screening urinary proten excretion of 0.15 g 、1.00g and 3.00g in 24-hour collection were detedmined by receiver operating characteristics ( ROC ) curve.Results There was a significant positive correlation between the urinary protein exeretion in 24-hour collections and Protein-to-creatinine ratio in first morning urine specimens.Such factors GFR 、sex 、age and BMI have nothing to do with the collection between p/c and tpu.urine protein exeretion in 24-hour collections ≥0.15 g,urine protein exeretion in 24-hour collections ≥ 1.00g and urine protein exeretion in 24-hour collections ≥ 3.00g.coresponding Protein-to-creatinine ratio clinical diagnosis best sensitive and specific spot:Protein-to-creatinine ratio ≥0.20g/gcr,Protein-to-creatinine ratio ≥0.95g/gcr,Protein-to-creatinine ratio ≥2.92 g/gct.Conclusions The Protein-to-creatinine ratio in spot urine samples can used as an alternative to urine protein excertion in 24-hour collections in patients. Key words: Kidney Diseases; Chronic Disease; Proteinuria; Creatinine