Abstract
Background: Chlorpyrifos is a widely used organophosphate pesticide. It exerts its toxic effect by inhibiting of cholinesterases and induction of oxidative stress. Methods: In the present study,Soya oil, Chlopyrifos,Moringa oleifera, Chlopyrifos + Moringa oleifera, were given to male rats through gavage for 2 weeks.The influence of chlorpyrifos on brain cholinesterase activity and indicators of oxidative stress malondialdehydecatalase, glutathione, superoxide dismutaseand also histopathological changes in the brain of Wistar rats was investigated compared to control group. Results: There was significant increase in the brain malondialdehyde of the chlopyrifos group compared to the control and chlopyrifos+Moringa oleifera group. Also there were significant decreases in the superoxide dismutase, catalase, glutathione and acetylcholinesterase concentrations in the chlopyrifosgroup compared to the control and chlopyrifos + Moringa oleifera group. The rats showed significant changes in body, liver, kidneys and heart weights No significant haematological changes were seen following treatment. While some histopathological changes were detected in brain tissues in the chlopyrifos treated group, less histopathological changes were observed in chlopyrifos +Moringa oleifera treated groups at the end of the 2 weeks’ study. Conclusion: Overall, these results support the hypothesis that chlopyrifos causes oxidative stress and Moringa oleiferaextract can help reduce the changes induced by chlopyrifos.
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