Morin Protects Human Respiratory Cells from PM2.5 Induced Genotoxicity by Mitigating ROS and Reverting Altered miRNA Expression.

Indhumathi Veerappan,Senthil Kumar Sankareswaran,Rajaguru Palanisamy

doi:10.3390/ijerph16132389

Indhumathi Veerappan, Senthil Kumar Sankareswaran + Show 1 more

Open Access

https://doi.org/10.3390/ijerph16132389

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Abstract

Chronic fine particulate matter (PM2.5) exposure causes oxidative stress and leads to many diseases in human like respiratory and cardiovascular disorders, and lung cancer. It is known that toxic responses elicited by PM2.5 particles depend on its physical and chemical characteristics that are greatly influenced by the source. Dietary polyphenolic compounds that possess antioxidant and free radical scavenging properties could be used for therapeutic or preventive approaches against air pollution related health hazards. This study evaluates characteristics and toxicity of PM2.5 collected from rural, urban, industrial, and traffic regions in and around Coimbatore City, Tamilnadu, India. Traffic PM2.5 particles contained higher amounts of metals and polycyclic aromatic hydrocarbons (PAHs). It also possessed higher levels of oxidative potential, induced more intracellular reactive oxygen species (ROS), and caused more levels of cell death and DNA damage in human respiratory cells. Its exposure up regulated DNA damage response related miR222, miR210, miR101, miR34a, and miR93 and MycN and suppressed Rad52. Pre-treatment with morin significantly decreased the PM2.5 induced toxicity and conferred protection against PM2.5 induced altered miRNA expression. Results of this study showed that cytoprotective effect of morin is due to its antioxidative and free radical scavenging activity.

Highlights

IntroductionEnvironmental pollution has become the major concern over human health in recent years
Environmental pollution has become the major concern over human health in recent years.According to World Health Organization, air pollution was found to be the reason for the death of nearly 4.2 million people worldwide in 2016
This study mainly focuses to reveal the protective nature of morin over the PM2.5 -induced genotoxicity by decreasing oxidative stress and altering miRNA

Summary

Introduction

Environmental pollution has become the major concern over human health in recent years. According to World Health Organization, air pollution was found to be the reason for the death of nearly 4.2 million people worldwide in 2016. Urban people are more exposed to the ambient particulate matters (PM) correlating to the exponentially increasing usage of vehicles and industrialization [1]. It is estimated that nearly 91% of urban people are exposed to particulate matters exceeding the WHO guided standards in 2016 [2]. PM are emitted by fuel combustion in vehicles, power plants, industries, households and from biomass burning [3].

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