Abstract
Myocardial infarction affects a large population in the world. Lipid peroxide metabolism plays an important role in the pathology of myocardial infarction. The present study was designed to investigate the antioxidant potential of morin, a flavonoid in isoproterenol (ISO)-induced myocardial infarction (MI), in rats. Male albino Wistar rats were pre-treated with morin (40 mg/kg), daily for a period of 30 days. After the treatment period, ISO (85 mg/kg), was subcutaneously injected in rats at an interval of 24 h for 2 days. ISO-administered rats showed elevated levels of thiobarbituric acid reactive substances (TBARS), and lipid hydro-peroxide (LOOH), in plasma and heart. Pretreatment with morin, the above changes were significantly reduced to near normal level. ISO-administered rats showed decrease in the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) in heart. In addition, decrease the levels non enzymatic antioxidants such as reduced glutathione (GSH), vitamin C and vitamin E in plasma and heart while ceruloplasmin in plasma. Pretreatment with morin, reversed these above biochemical changes towards normalcy. These findings revealed that, the morin possess antioxidant activity in experimentally induced cardiac toxicity.
Highlights
Myocardial infarction is a clinical syndrome arising from sudden and persistent curtailment of myocardial blood supply which results in the necrosis of the myocardium (Anversa and Sonnenblick, 1990)
Our study shows that pretreatment with morin, a flavonoid ameliorates adenosine triphosphatases and glycoproteins and exhibits beneficial role on cardiac mitochondrial function during ISO induced myocardial infarction in male Wistar rats (Al-Numair et al, 2012; Al-Numair et al, 2012)
Rats induced with ISO, showed a significant (P
Summary
Myocardial infarction is a clinical syndrome arising from sudden and persistent curtailment of myocardial blood supply which results in the necrosis of the myocardium (Anversa and Sonnenblick, 1990). This is usually followed by numerous pathophysiological and biochemical changes including lipid peroxidation and hyperlipidemia (Suchalatha and Shyamala-Devi, 1990). Results : ISO-administered rats showed elevated levels of thiobarbituric acid reactive substances (TBARS), and lipid hydro-peroxide (LOOH), in plasma and heart. Conclusion: Pretreatment with morin, reversed these above biochemical changes towards normalcy These findings revealed that, the morin possess antioxidant activity in experimentally induced cardiac toxicity
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