Abstract
Histological and histochemical analysis was performed on blood vessel samples taken from the amputated lower limbs due to gangrene. The limbs of 9 patients who had clinically diagnosed and patho-histologically confirmed thromboangiitis obliterans (TAO, Buerger's disease) and of 8 patients with atherosclerotic obturation of blood vessels lumen (ASO) were amputated. A comparison of pathohistological findings was performed, aimed at determining morphological criteria for differential diagnosis of these two diseases, as well as other blood vessel diseases which is of extreme importance for the therapeutic treatment. The examinations showed that the characteristic for TAO were, apart from the already known criterion - presence of microabscess with giant cells in inflamed thrombus in the lumen of arteries and veins, the following pathohistological findings as well: presence of the newly formed blood vessels in inflamed thrombus of a bulb shape, adventitial fibrosis without media fibrosis, winding and reduplicated intact internal elastic lamina, oedema and loose tissue under external elastic lamina, oedema of endothelial cells ofvasa vasorum and lack of media atrophy.
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