Abstract
To evaluate focal changes morphology the authors carried out a retrospective analysis in 297 patients who had earlier underwent surgery for different forms (multinodular/nodular) of goiter. In all cases preoperative US examination revealed thyroid nodules and focal lesions under 1 cm in the surrounding thyroid tissue. The results after US study taken part in the preoperative period were compared with histological examination data. Average patients age was 47.4 ± 11.9; median was 48 [17; 81]. For evaluation expression of a proliferation marker (Ki 67) and a development of a functional independence (TSH receptor) in the focuses of goiterous transformation at an immunnohistochemical study was formed a group of 25 cases (14 — focal hyperplasia and 11 — focal hypertrophy). 78.8% of focal changes were morphologically represented with goiterous or dystrophic origin (focuses of sclerosis, lymphoid infiltration and atrophy). Amongst them 56.6% were focal goiterous hypertrophy and hyperplasia. Evidently and moderately marked Ki 67 expression and negative expression of TSH-receptor in the focuses of goiterous hyperplasia proved the tendency to their growth with further transformation into colloid nodules and functional independence development.
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