Abstract
The ability to measure protein half-lives on a large scale in human cells should contribute to our understanding of a variety of physiological and pathological processes. In order to meet this goal, Eden et al. (p. [764][1], published online 13 January; see the Perspective by [Plotkin][2] ) developed a method called bleach-chase. Bleach-chase was used to reveal an unexpectedly simple response of fluorescently tagged protein half-lives to stresses and to drugs that stop cell division: Long-lived proteins become longer-lived. It appears that changes in cell growth cause changes in the intra cellular dilution rates of proteins, which are not balanced by corresponding changes in active protein degradation. [1]: /lookup/volpage/331/764 [2]: /lookup/volpage/331/683?iss=6018
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