Abstract
To the Editor: Reurink et al. (June 26 issue)1 report no benefit of intramuscular platelet-rich plasma (PRP) injections in patients with acute hamstring injuries. The delayed administration and low dosage of PRP injections in their trial may well have rendered PRP injections ineffective. Growth factors in PRP exert an antiapoptotic, chemotactic, antiinflammatory, and proliferative effect on fibroblasts, neurons, and myoblasts; some of these effects are dose-dependent and strongly influence myogenesis, angiogenesis, and fibrogenesis.2 These events occur a few hours after muscle damage. By the time PRP injections are administered (within 5 days after the injury), many of the injured microenvironmental . . .
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