Abstract

The current issue of the Journal includes a study by Narula et al (1) (pages 421–426) that nicely demonstrates the numerous reasons why fecal occult blood test (FOBT) use outside of screening purposes should be considered inappropriate and how it may, in fact, negatively impact patient care. The authors performed a chart review of all FOBTs ordered in Hamilton Health Sciences’ (Hamilton, Ontario) acute care campuses over a three-month period in 2011, combined with a survey of health care providers on their practices regarding the use of FOBT. Use of point-of-care FOBT was not included. The clinical presentations were anemia, overt or suspected gastrointestinal (GI) bleeding, diarrhea, iron deficiency and dyspepsia. Thirty-four percent of patients underwent ≥2 FOBTs, and the majority of tested patients were either on medications or on a diet that could interfere with the test. Only 50% of the FOBT positives were ever referred for a GI consultation and, most importantly, 27% of patients presenting with overt GI bleeding in whom an FOBT was ordered experienced a delay in the GI referral because of the FOBT process. The survey included 67 health care professionals (mainly primary care physicians and nurses); the most common reasons for ordering an FOBT were: symptoms potentially consistent with GI bleeding (84%); anemia (53%); iron deficiency with or without anemia (31%); overt GI blood loss (26%); and nonbloody diarrhea (10%). Interestingly, screening for colorectal cancer was a cited reason in only 25% of the cases.

Highlights

  • The results were similar to those reported in a retrospective review of FOBT use in 15 hospitals during 2005 in the Netherlands [2], where it was shown that FOBT misuse creates a diagnostic delay

  • A meta-analysis examining the use of diagnostic tests to help identify individuals who are most likely to have an underlying malignancy among patients presenting with nonacute lower abdominal symptoms [3,4] concluded that the use of FOBT and the fecal immunochemical test (FIT) in such patients had high sensitivity and specificity

  • Colorectal cancer screening programs that rely on primary care physicians to initiate screening or distribute FOBT kits are faced with problems of kit distribution to individuals who are not eligible for screening

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Summary

Introduction

Both studies support the same simple conclusion: FOBT should not be used for purposes other than screening, and patients presenting with symptoms suggestive of an underlying malignancy or iron deficiency anemia require endoscopic evaluations. A meta-analysis examining the use of diagnostic tests to help identify individuals who are most likely to have an underlying malignancy among patients presenting with nonacute lower abdominal symptoms [3,4] concluded that the use of FOBT and the fecal immunochemical test (FIT) in such patients had high sensitivity and specificity.

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