More of a good thing or less of a bad thing: gene copy number variation in polyploid cells of the placenta.

James C Cross,Marisa S Bartolomei

doi:10.1371/journal.pgen.1004330

Abstract

More of a good thing or less of a bad thing: gene copy number variation in polyploid cells of the placenta.

Highlights

Nature demonstrates many interesting variations in cell cycles and cell growth (Figure 1A)
Distinct trophoblast giant cells (TGC) subtypes sit at different positions within the maternal blood space in the placenta [5,6]
A distinct TGC subtype invades the maternal arteries that bring blood to the implantation site to replace the endothelial cells, while vascular spaces within the placenta itself are formed by morphogenesis of other TGC subtypes into tube-like structures [4]

Summary

Introduction

Nature demonstrates many interesting variations in cell cycles and cell growth (Figure 1A). Distinct TGC subtypes sit at different positions within the maternal blood space in the placenta [5,6]. A distinct TGC subtype invades the maternal arteries that bring blood to the implantation site to replace the endothelial cells, while vascular spaces within the placenta itself are formed by morphogenesis of other TGC subtypes into tube-like structures [4].

Results

Conclusion