Abstract

Deeper endotracheal intubation (DET) were proposed to improve cervical esophageal endoscopic submucosal dissection (CE-ESD) due to the limited space and visibility. We aimed to evaluate the efficacy and safety of the DET. In current dual-center trial, patients were randomized into deeper or conventional endotracheal intubation (CET) group. Complete resection rate, operation time and adverse events were measured and compared. 59 patients (60 lesions) were assigned to the groups, showing comparable baseline characteristics. The complete resection rates were similarly high in both groups. However, DET significantly reduced ESD operation time (52.2 min vs. 71.1 min, p<0.001) and postoperative pain scores (3.1 vs. 4.7, p<0.01). Severe stenosis occurred more frequently in the CET patients (20% vs. 0%, p=0.035). No significant differences were observed in other adverse events. DET can overcome technical challenges to improve the therapeutic efficiency and safety.

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