Abstract
BackgroundNonmotor symptoms are probably present prior to, early on, and following, a diagnosis of Parkinson's disease. Nonmotor symptoms may hold important information about the progression of Parkinson's disease.ObjectiveTo evaluated the total early and prediagnostic morbidities in the 3 years before a hospital contact leading to a diagnosis of Parkinson's disease.MethodsRetrospective morbidity data from Danish National Patient Registry records (1997–2007) of 10,490 adult patients with a secondary care diagnosis of Parkinson's disease were compared with 42,505 control cases.ResultsParkinson's disease was associated with significantly higher morbidity rates associated with conditions in the following categories: mental and psychiatric, nervous system, gastrointestinal, musculoskeletal system and connective tissue, genitourinary, abnormal clinical and laboratory findings, injury, poisoning and certain other external causes, and other factors influencing health status and contact with health services. It was negatively associated with neoplasm, cardiovascular, and respiratory diseases.ConclusionsPatients with a diagnosis of Parkinson's disease present significant differences in morbidities early on, following, and prior to, their diagnosis, compared with healthy controls.
Highlights
Parkinson’s disease (PD) is a serious neurodegenerative disorder that affects a significant proportion of the adult population (Wickremaratchi et al 2009; McCrone et al 2011)
The morbidities, subdivided into percentage incidence and Odds ratios (ORs) with 95% confidence intervals (CIs), are shown in Table 2 for diagnoses made in more than 1% of PD patients (Table 3)
We could not confirm the former finding because we found lower incidences of neoplasm before PD diagnosis
Summary
Parkinson’s disease (PD) is a serious neurodegenerative disorder that affects a significant proportion of the adult population (Wickremaratchi et al 2009; McCrone et al 2011). The underlying pathophysiology includes progressive destruction of multiple brain regions, especially, initially, the brain stem, the basic forebrain, the extrapyramidal system, and, in later stages, the cortical areas (Braak et al 2003a). Results: Parkinson’s disease was associated with significantly higher morbidity rates associated with conditions in the following categories: mental and psychiatric, nervous system, gastrointestinal, musculoskeletal system and connective tissue, genitourinary, abnormal clinical and laboratory findings, injury, poisoning and certain other external causes, and other factors influencing health status and contact with health services. It was negatively associated with neoplasm, cardiovascular, and respiratory diseases. Conclusions: Patients with a diagnosis of Parkinson’s disease present significant differences in morbidities early on, following, and prior to, their diagnosis, compared with healthy controls
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