Abstract
BackgroundEarly identification of persons with undiagnosed HIV infection is an important health care issue. We examined associations between diseases diagnosed in hospitals and risk of subsequent HIV diagnosis.MethodsIn this population-based case control study, cases were persons with incident HIV infection diagnosed in Denmark between 1 January 1995 and 1 June 2008. Risk-set sampling was used to identify 19 age- and gender-matched population controls for each HIV case, using the HIV diagnosis date as the index date for both cases and controls. Prior hospital diagnoses obtained from Danish medical databases were first categorized into 22 major disease categories (excluding AIDS-defining diseases except tuberculosis) and then subdivided into 161 subcategories, allowing us to examine specific diseases as potential HIV indicators by conditional logistic regression.ResultsThe study included 2,036 HIV cases and 35,718 controls. Persons with the following disease categories had a high risk of HIV diagnosis during the subsequent 5-year period: sexually transmitted infections and viral hepatitis (adjusted odds ratio [aOR] = 12.3, 95% CI: 9.60–15.7), hematological diseases (aOR = 4.28, 3.13–5.85), lower respiratory tract infections (aOR = 3.98, 3.14–5.04)), CNS infections (aOR = 3.44, 1.74–6.80), skin infections (aOR = 3.05, 2.47–3.75), other infections (aOR = 4.64, 3.89–5.54), and substance abuse (aOR = 2.60, 2.06–3.29). Several specific diseases were associated with aORs >20 including syphilis, hepatitis A, non “A” viral hepatitis, herpes zoster, candida infection, endocarditis, thrombocytopenia, and opioid abuse.ConclusionsTargeted testing for HIV in patients diagnosed with diseases associated with HIV may lead to earlier treatment and thereby reduced morbidity, mortality and HIV transmission.
Highlights
Despite three decades of concerted effort, the HIV epidemic remains a tremendous public health challenge in both low- and high-income countries [1,2]
Many individuals newly diagnosed with HIV present at a late stage of the disease with severe immune depletion, resulting in delayed initiation of antiretroviral therapy (ART) which worsens their prognosis [3] and increases further transmission of HIV [4,5,6]
The U.S Centers for Disease Control and Prevention (CDC) recommend routine HIV testing for all persons under age 65 who come into contact with the health care system [10]
Summary
Despite three decades of concerted effort, the HIV epidemic remains a tremendous public health challenge in both low- and high-income countries [1,2]. The U.S Centers for Disease Control and Prevention (CDC) recommend routine HIV testing for all persons under age 65 who come into contact with the health care system [10]. While this approach may be cost-effective in areas with high HIV prevalence [11] and does prolong life expectancy [3], alternative approaches such as targeted HIV testing may be more appropriate in other settings with lower HIV prevalence or different health care systems [2]. We examined associations between diseases diagnosed in hospitals and risk of subsequent HIV diagnosis
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
