Morbidity and risk factors of metabolic syndrome in different phenotypes of polycystic ovary syndrome

Abstract

Objective To test the hypothesis that different phenotypes Chinese women with polycystic ovary syndrome(PCOS) have various risk of metabolic syndrome(MS) and different metabolic phenotypes.Methods This was a prospective case-control study.A total of 305 women were diagnosed as PCOS based on the 2003 Rotterdam criteria.123 women with regular menstrual cycles and without hyperandrogenism were recruited and served as controls.PCOS patients were divided into two subgroups:according to their phenotypes with and without hyperandrogenism.The diagnosis of MS was based on 2005 modified International Diabetes Federation criteria.Results The prevalence of MS was 12.3％ in PCOS without hyperandrogenism,22.9％ in PCOS with hyperandrogenism,both significantly higher than 6.5％ in control group (P＜0.05).The rates of MS components,except for the fasting glucose level and blood pressure,all were significantly higher in both PCOS groups than those in control group(both P＜0.05).Furthermore,the triglyceride level was significantly higher in PCOS women without hyperandrogenism than that in PCOS women with hyperandrogenism as well as control women (both P＜0.05).The incidence of lowered high density lipoprotein-cholesterol (HDL-C) level was the highest in PCOS women with hyperandrogenism.The disposition index(DI) and Matsuda Index in PCOS women with and without hyperandrogenism were significantly lower compared with the control subjects after adjustment for body mass index (BMI,all P ＜O.05).However,there was no significant difference in DI and Matsuda Index between PCOS women with and without hyperandrogeuism.The results of logistic regression analysis revealed that Matsuda Index and BMI were the independent predictors of MS (both P ＜ 0.05).Conclusion Obesity and Matsuda Index are the independent predictors of MS in PCOS women.PCOS women with hyperandrogenism have high risk of MS.The rates of MS components in PCOS women with and without hyperandrogenism are different. Key words: Polycystic ovarian syndrome; Phenotype; Metabolic syndrome; Obesity