Abstract
BackgroundUnion between second cousins and closer relatives is called consanguineous marriage. Consanguineous marriage is associated with increased risk of autosomal recessive diseases and several multifactorial traits. In order to evaluate the association between prevalence/mortality of COVID-19 and the frequency of consanguineous marriage, the present ecologic study was carried out. For the present study, data of prevalence (per 106 people) and mortality (per 106 people) and number of performed laboratory diagnostic test (per 106 people) of COVID-19 disease at four time points (December 2020; March, August and October 2021) of 65 countries were used.ResultsUnivariable correlation and generalized estimating equation analysis were used. In analysis, prevalence and mortality of COVID-19 were used as dependent variables and human development index, number of performed diagnosis test and the mean of inbreeding coefficient (α-value) were introduced into model as covariates, and time point was used as a factor in analysis. The square root (SR) of prevalence (P = 0.008) and SR-mortality (P < 0.001) of COVID-19 negatively associated with the log-transformed of α-value.ConclusionsThe present finding means that in countries with high levels of consanguineous marriages, the prevalence of COVID-19 and mortality due to COVID-19 were lower than countries having low level of marriage with relatives.
Highlights
Union between second cousins and closer relatives is called consanguineous marriage
The current study revealed that in countries with high levels of consanguineous marriages, the prevalence of COVID-19 and mortality due to COVID-19 were lower than countries having low frequency of marriage with relatives
Average levels of consanguinity and COVID-19 epidemiologic parameters for countries were used for analysis
Summary
Union between second cousins and closer relatives is called consanguineous marriage. Consanguineous marriage is associated with increased risk of autosomal recessive diseases and several multifactorial traits. In order to evaluate the association between prevalence/mortality of COVID-19 and the frequency of consanguineous marriage, the present ecologic study was carried out. Union between second cousins and closer relatives is called consanguineous marriage [1]. The frequency of consanguineous marriage has geographical distribution; it has high prevalence in several Asia and Africa countries. Numerous studies have shown that this type of marriage is associated with increased risk of autosomal recessive diseases and several multifactorial traits [1, 8–15]. There is significant association between parental consanguineous marriage and the risk of some infections [17, 18]
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