Abstract
Introduction: Organ phosphorus (OP) toxicity has been studied extensively because of its world wide use. Toxicity of organophosphates is the result of inhibition of acetyl cholinesterase resulting in cholinergic signs. Aim of the Work: To evaluate initial indicators that can indicate prognosis of patients in OP poisoning. Materials and Methods: A retrospective study conducted in Zagazig university hospital over a year. OP poisoning was clinically diagnosed with history of OP compound exposure and confirmed by low pseudo cholinesterase levels. Results: In the present study, 76 patients were enrolled. Major cases were male. High mortality rates were in the youth and in prolonged ventilated patients. The mortality rate was proportionally related to lag time after exposure and plasma pseudo cholinesterase levels. Electrolyte disturbance did not affect clinical outcome. Conclusion: From this study, it could be concluded that mortality is directly proportionate to the lag time, amount of OP consumed, clinical severity, pseudo cholinesterase levels and duration of ventilator support. This study helps in rapid diagnosis, and rapid early and effective treatment, which may result in decreasing the morbidity and mortality rates. Recommendation: It is recommended to increase awareness regarding the rapid diagnosis, and rapid effective treatment of organ phosphorous.
Highlights
Organ phosphorus (OP) toxicity has been studied extensively because of its world wide use
This study helps in rapid diagnosis, and rapid early and effective treatment, which may result in decreasing the morbidity and mortality rates
Total leucocytes counts and pseudo cholinesterase levels were done to all patient and they are treated according to the standard protocol in the hospital by Decontamination, atropine, obidoxime and mechanical ventilation to the required patients [9]
Summary
Organ phosphorus (OP) toxicity has been studied extensively because of its world wide use. OP poisoning was clinically diagnosed with history of OP compound exposure and confirmed by low pseudo cholinesterase levels. The mortality rate was proportionally related to lag time after exposure and plasma pseudo cholinesterase levels. Conclusion: From this study, it could be concluded that mortality is directly proportionate to the lag time, amount of OP consumed, clinical severity, pseudo cholinesterase levels and duration of ventilator support. This study helps in rapid diagnosis, and rapid early and effective treatment, which may result in decreasing the morbidity and mortality rates. The biomarker detection and identification of exposure are important for the diagnosis and treatment of poisoning, in addition to health monitoring for specific workers [2]. Organophosphate (OP) inhibits the enzyme acetyl cholinesterase increasing acetylcholine in muscarinic and nicotinic receptors in the peripheral and central nervous systems [3]
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