Abstract
Moonlighting proteins comprise a class of multifunctional proteins in which a single polypeptide chain performs multiple biochemical functions that are not due to gene fusions, multiple RNA splice variants, or pleiotropic effects. The known moonlighting proteins perform a variety of diverse functions in many different cell types and species, and information about their structures and functions is scattered in many publications. We have constructed the manually curated, searchable, internet-based MoonProt Database (http://www.moonlightingproteins.org) with information about the over 200 proteins that have been experimentally verified to be moonlighting proteins. The availability of this organized information provides a more complete picture of what is currently known about moonlighting proteins. The database will also aid researchers in other fields, including determining the functions of genes identified in genome sequencing projects, interpreting data from proteomics projects, and annotating protein sequence and structural databases. In addition, information about the structures and functions of moonlighting proteins can be helpful in understanding how novel protein functional sites evolved on an ancient protein scaffold, which can also help in the design of proteins with novel functions.
Highlights
2703-Pos Board B133 Probing and Manipulating Enzyme Activity and Conformational Dynamics by Single-Molecule Afm-FRET and Magnetic Tweezers-FRET Ultramicroscopy Qing Guo, Yufan He, H
Since the monounsaturated products of Stearoyl-CoA desaturase (SCD) are key precursors of membrane phospholipids, cholesterol esters, and triglycerides, SCD is pivotal in fatty acid metabolism
SCD1 is an integral membrane protein located in the endoplasmic reticulum, and catalyzes the formation of a cis-double bond between the 9th and 10th carbons of stearoyl- or palmitoyl-CoA
Summary
2703-Pos Board B133 Probing and Manipulating Enzyme Activity and Conformational Dynamics by Single-Molecule Afm-FRET and Magnetic Tweezers-FRET Ultramicroscopy Qing Guo, Yufan He, H. 2702-Pos Board B132 X-Ray Structure of a Mammalian Stearoyl-Coa Desaturase-1 Yonghong Bai, Jason G. Baylor College of Medicine, Houston, TX, USA.
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