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Abstract
Several review articles on phenotypes of gastroesophageal reflux disease (GERD)1–4 prompted me to reflect on my views about the status of GERD in 2021. I have been caring for patients with esophageal disorders and GERD and engaged in research on the physiology and pathophysiology of GERD and the genesis of heartburn and esophageal pain since 1983. The 1980s was an exciting time for the esophagus because that was when the revolutionary proton pump inhibitors (PPIs) emerged as an effective treatment for erosive esophagitis.
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