Abstract
BackgroundThe Montreal Cognitive Assessment (MoCA) is known to have discriminative power for patients with Mild Cognitive Impairment (MCI). Recently Cognitive Reserve (CR) has been introduced as a factor that compensates cognitive decline. We aimed to assess whether the MoCA reflects CR. Furthermore, we assessed whether there were any differences in the efficacy between the MoCA and the Mini-Mental State Examination (MMSE) in reflecting CR.MethodsMoCA, MMSE, and the Cognitive Reserve Index questionnaire (CRIq) were administered to 221 healthy participants. Normative data and associated factors of the MoCA were identified. Correlation and regression analyses of the MoCA, MMSE and CRIq scores were performed, and the MoCA score was compared with the MMSE score to evaluate the degree to which the MoCA reflected CR.ResultsThe MoCA reflected total CRIq score (CRI; B = 0.076, P < 0.001), CRI-Education (B = 0.066, P < 0.001), and CRI-Working activity (B = 0.025, P = 0.042), while MMSE reflected total CRI (B = 0.044, P < 0.001) and CRI-Education (B = 0.049, P < 0.001) only. The MoCA differed from the MMSE in the reflection of total CRI (Z = 2.30).ConclusionIn this study, we show that the MoCA score reflects CR more sensitively than the MMSE score. Therefore, we suggest that MoCA can be used to assess CR and early cognitive decline.
Highlights
The Montreal Cognitive Assessment (MoCA) is known to have discriminative power for patients with Mild Cognitive Impairment (MCI)
Pearson correlation was performed between MoCA, Mini-Mental State Examination (MMSE) and Cognitive Reserve Index questionnaire (CRIq) scores (Table 3)
Semi-partial correlation analysis adjusting sex was performed in order to find relation between MoCA, MMSE, and CRIq scores adjusting the effect of sex because age and years of education were already adjusted in CRIq and it showed comparable results (Additional file 1: Table A2)
Summary
The Montreal Cognitive Assessment (MoCA) is known to have discriminative power for patients with Mild Cognitive Impairment (MCI). We assessed whether there were any differences in the efficacy between the MoCA and the Mini-Mental State Examination (MMSE) in reflecting CR. The number of patients with dementia has increased worldwide. This increase emphasizes the importance of early detection and treatment of dementia. The Montreal Cognitive Assessment (MoCA) is known to distinguish patients with Mild Cognitive Impairment (MCI) from the normal population [1]. MoCA has shown higher sensitivity in detecting cognitive decline than the Mini-Mental State Examination (MMSE) [2], another common clinical screening tool for Alzheimer’s disease (AD).
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
