Abstract
A oligomer toxicity has been postulated in absence of As-plaques correlation with the clinical severity. Methods.– With immunohistological methods the distribution of As-oligomers, amyloid plaques and NFTs has been studied in the hippocampal formation, the temporal neocortex as well as in the frontal and occipital cortical areas, in 74 cases (43 to 104years old). Results.– A parallel evolution in the presence and the severity of As-oligomers and plaques has been observed in all the studied areas. Moreover, in aging brain the microvascular pathology is also frequent as well as the progressive accumulation of vascular lesions throughout the human lifespan. The microvasculature changes in advanced age and the vascular pathology, including amyloid angiopathy, increases with age. Conclusions.– Oligomers and As deposition show a parallel evolution in both normal and pathological aging. The anatomical inter-individual variability, mainly of the entorhinal cortex, is very important and could be related to functional reserve at the onset of cognitive decline.
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