Montmorillonite K-10 Clay as an Efficient Reusable Heterogeneous Catalyst for the Solvent-Free Microwave Mediated Synthesis of 5-Substituted 1H-Tetrazoles

Abstract

Department of Chemistry, Faculty of Sciences, Islamic Azad University, Lahijan Branch, Lahijan, IranReceived August 4, 2011, Accepted September 14, 2011Various 5-substituted 1H-tetrazole derivatives were synthesized in a simple and environmentally benignmethod from the reaction of aryl and benzyl nitriles with sodium azide in solvent-free media usingmontmorillonite K-10 clay as solid recyclable heterogeneous acidic catalyst and microwave irradiation in goodyields and short reaction times.Key Words : Montmorillonite K-10 clay, 5-Substituted 1 H-tetrazoles, Solvent-free, Microwave irradiationIntroductionTetrazoles, while not found in nature, have gained con-siderable popularity in drug discovery efforts.