Montmorillonite K10 Catalysed Condensation of 1-(3-Chlorophenyl)-4-(3-chloropropyl) piperazine and 1,2,4-Triazolo [4,3-a]pyridine-3-(2H)-one: A Proficient and Green Synthesis of Trazodone Hydrochloride and Its Analogues

Abstract

Montmorillonite K10 clay has an extremely significant heterogeneous catalyst for condensation reaction with high yield of the product as compared to other reported reagents. Background: Novel green, synthetic methodology has been adopted for the synthesis of 2-[3-{4-(3-chlorophenyl)-1-piperazinyl}propyl]-1,2,4-triazolo[4,3-a] pyridine-3-(2H)-one hydrochloride (5) analogues using Montmorillonite K10 (MK10) as an effective-efficient heterogeneous catalyst. The present synthesis offers various significant features with numerous advantages such as outstanding yields, operational simplicity, recyclability and reusability of the catalyst for this synthetic reaction. Methods and findings: Condensation reaction is the only exceptional tool for the synthesis of numerous biologically significant organic compounds. In the current investigation, condensation of 1-(3-chlorophenyl)-4-(3-chloropropyl) piperazine (3) and 1,2,4-triazolo[4,3-a]pyridine-3-(2H)-one (4) in the presence of MK10 under thermal condition has been carried out with afford the corresponding products i.e., (5) analogues with good yields (88-95%) over conventional reagents. MK10 is such a heterogeneous catalyst which can be completely recovered and reusable for a three times without potential loss in its catalytic activity.