Abstract
The rapid and highly efficient synthesis of 5,5-disubstituted hydantoins achieved by three-component condensation of corresponding ketones and aldehydes, potassium cyanide and ammonium carbonate in an additional reaction under ultrasound irradiation by using montmorillonite K-10 as a heterogenous catalyst. Utilizing ultrasound irradiation and montmorillonite in this method has several benefits, for example short reaction time, high yield and use of recyclable catalyst. A convenient and facile method for synthesis of hydrantoin derivatives using substituted aldehydes and ketones in the presence of H2O/EtoH by montmorillonite as a useful catalyst under ultrasound irradiation is discussed.
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