Montmorillonite K-10 Clay Mediated Green Synthesis of 2-Amino-4-aryl thiazole Derivatives from α-Brominated Aralkyl Ketones in Water

Abstract

Montmorillonite K-10 clay has been identified as an efficient and green catalyst for the synthesis of 2-amino-4-aryl thiazole derivatives (3) in good to excellent isolated yields (80-96%) from α-brominated aralkyl ketones (1) and thiourea (2) in aqueous medium at 25-30°C. The present procedure offers advantages of short reaction time, simple work-up, high yields of products and the catalyst is environmentally benign and exhibits remarkable reusable activity by four times. Keywords: Montmorillonite K-10 clay, phenacyl bromides, thiourea, water, 2-amino-4-aryl thiazoles.