Abstract
Penalized likelihood (PL) image reconstruction has been developed for emission tomography to improve the image quality of reconstructed images. One challenge in PL reconstruction is that the selection of a proper regularization parameter to achieve a balance between the likelihood function and penalty function can be difficult. Here we present a novel method to choose the regularization parameter by minimizing Stein's unbiased risk estimate (SURE), which is an unbiased estimator of the true mean square error (MSE) of the PL reconstruction. A Monte-Carlo method is developed to compute SURE. Simulation studies are conducted based on a real PET scanner. Results show that the Monte Carlo SURE provides a practical and reliable way to select the optimum regularization parameter to minimize the total predicted mean squared error.
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