Monte carlo autofluorescence modeling on cervical dysplasia

Abstract

We present autofluorescence modeling of different cervix tissue dysplasia for clinical diagnosis. We used double integrating sphere system and inverse adding-doubling (IAD) method to evaluate tissue optical parameters (absorption coefficient, /spl mu//sub a/, scattering coefficient, /spl mu//sub s/) of different cervix dysplasia. We used fluorescence Monte Carlo model included absorption coefficient and scattering coefficient from IAD and integrate sphere, to simulate autofluorescence spectra. The results show the increasing thickness of abnormal tissue on the cervical epithelium accompanied with the decreasing in autofluorescence intensity, in collagen peak (390 nm) and in NADH peak (460 nm), along with the lesion developments.