Abstract
Because the brain edema has a crucial impact on morbidity and mortality, it is important to develop a noninvasive method to monitor the process of the brain edema effectively. When the brain edema occurs, the optical properties of the brain will change. The goal of this study is to access the feasibility and reliability of using noninvasive near-infrared spectroscopy (NIRS) monitoring method to measure the brain edema. Specifically, three models, including the water content changes in the cerebrospinal fluid (CSF), gray matter and white matter, were explored. Moreover, these models were numerically simulated by the Monte Carlo studies. Then, the phantom experiments were performed to investigate the light intensity which was measured at different detecting radius on the tissue surface. The results indicated that the light intensity correlated well with the conditions of the brain edema and the detecting radius. Briefly, at the detecting radius of 3.0[Formula: see text]cm and 4.0[Formula: see text]cm, the light intensity has a high response to the change of tissue parameters and optical properties. Thus, it is possible to monitor the brain edema noninvasively by NIRS method and the light intensity is a reliable and simple parameter to assess the brain edema.
Highlights
Patients usually su®er from the brain edema when they sustain the brain damage and diseases, such as cerebrovascular diseases, encephalitides and brain tumors.[1]
The light intensity was obtained at the specic detecting radius of [1.0, 2.0, 3.0, 4.0, 5.0] cm on the tissue surface
With the increase of CSF thickness, the light intensity increases greatly at the detecting radius of 4.0 cm, while the light intensity decreases little at the detecting radius of 2.0 cm
Summary
Patients usually su®er from the brain edema when they sustain the brain damage and diseases, such as cerebrovascular diseases, encephalitides and brain tumors.[1] Brain edema is dened as the increase of the water content in brain parenchyma, which has a. This is an Open Access article published by World Scientic Publishing Company. ICP,[5,6] measured by invasive method, is regarded as the golden standard procedure for the diagnosis of the brain edema. The sensitivity of these methods is still needed to be improved
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