Abstract
A case is reported of an 11-year-old girl with Ph 1-positive chronic granulocytic leukemia. Very early in her illness the original 46,XX,t(9:22) cell population in the marrow became replaced by a second abnormal cell line, 45,XX,−7. This hypodiploid clone then remained dominant in the marrow until her death from myeloid blast crisis over 3 years later. It is suggested that the 45,XX,−7 cell line may have been induced by chemotherapy, and this possibility is discussed with particular reference to similar changes seen in secondary ANLL following treatment for lymphomas and other hematological malignancies.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callSimilar Papers
More From: Cancer Genetics and Cytogenetics
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
