Abstract
Two mononuclear Pd(II) complexes [PdCl2(pfptp)] (1) and [PdCl2(pfhtp)] (2), with ligands 2-(3-perfluoropropyl-1-methyl-1,2,4-triazole-5yl)-pyridine (pfptp) and 2-(3-perfluoroheptyl-1-methyl-1,2,4-triazole-5yl)-pyridine (pfhtp), were synthesized and structurally characterized. The two complexes showed a bidentate coordination of the ligand occurring through N atom of pyridine ring and N4 atom of 1,2,4-triazole. Both complexes showed antimicrobial activity when tested against both Gram-negative and Gram-positive bacterial strains.
Highlights
In the last decade, the emergence of multi-drug resistant (MDR) bacterial strains has been considered a concern worldwide [1]
Bacterial infections in clinical and veterinary environments can frequently be due to different MDR bacterial strains, such as Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), etc. [2,3]
We have explored the antimicrobial activity of new Pd(II) complexes with 3-perfluoroalkyl-1-methyl-1,2,4-triazolyl-pyridine ligands
Summary
The emergence of multi-drug resistant (MDR) bacterial strains has been considered a concern worldwide [1]. Bacterial infections in clinical and veterinary environments can frequently be due to different MDR bacterial strains, such as Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), etc. In the frame of our study, we have previously synthesized, characterized and investigated the biological activity of Pt(II) complexes with 2-(5-perfluoropropyl)1,2,4-oxadiazole-3yl)-pyridine (pfpop), 2-(5-perfluoroheptyl-1,2,4-oxadiazole-3yl)-pyridine (pfhop), 2-(3-perfluoropropyl-1-methyl- 1,2,4-triazole-5yl)-pyridine (pfptp), and 2-(3-perfluoroheptyl-1methyl-1,2,4-triazole-5yl)-pyridine (pfhtp) ligands, finding interesting data concerning both antitumor and antimicrobial activity [4,5]. Because of the severe side effects of complexes, such as cisplatin [6], in the treatment of several carcinomas, and of the cancer resistance mechanisms against the clinically utilized drug doses, in recent years, the research has been moving toward the tentative toxicity reduction of Pt(II). An interesting review of the mechanistic insight on different mononuclear
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
