Abstract
Characteristics of monolayers of 15 new amphiphilic α-, β-, and γ-cyclodextrins at the air−water interface are reported. The modification involves substitution at the positions C-6 of the cyclodextrin with S-phenyl, S-(4-bromophenyl), S-(4-n-butoxyphenyl), S-(4-n-pentylphenyl), and S-(4-nitrophenyl). Even simple thiophenol-substituted cyclodextrins exhibit good amphiphilic properties, and the sequence of increasing degree of organization and stability of the monolayers is given. Increasing hydrophobicity of the group attached to the position C-6 results in the increase of the stability of the monolayer. However, for highly substituted cyclodextrins agglomeration of the molecules at the air−water interface was observed. This problem displayed by mean molecular areas smaller than those obtained from the crystal structures can be overcome by using more diluted spreading solutions. The β-series was found to deviate from other cyclodextrins in that the collapse surface pressure is higher than and almost independent of the substituent. This was ascribed to the 7-fold symmetry of β-cyclodextrin molecules.
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