Abstract
The present study aimed to i) assess the prognostic value of monoethylglycinexylidide (MEGX) formation kinetics in predicting liver dysfunction in patients with severe sepsis, and ii) to compare it with other oxygen indices and with gastric mucosal pH (pHi). Twenty-seven patients meeting the criteria for severe sepsis were prospectively evaluated. Patients with haemodynamic instability, elevated liver enzymes (>2 × normal) and bilirubin levels (>3 mg/dl), coagulation disorders and gastro-intestinal bleeding were not included. A gastric tonometer (TRIP, Tonometrics, Worcester, MA, USA) was introduced in all patients. Gastric pHi was calculated using the Henderson-Hasselbalch equation. Oxygen delivery (DO2) was calculated by the simplified formula DO2 =CI×CaO2, where CI is cardiac index and CaO2 is arterial oxygen content. Oxygen consumption (VO2) was determined by indirect calculation of the product of CI and arteriovenous oxygen content difference. Plasma aspartate aminotransferase, alanine aminotra...
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