Abstract
We report a simple and low cost methodology to synthesize sodium oleate coated magnetite nanoparticles for hyperthermia applications. The system consists of oleate coated magnetite nanoparticles with large susceptibility (1065emu/gT), induced by the dipolar inter-particle interaction, with a magnetic core diameter in the 6nm–12nm size range. In aqueous medium, the nanoparticles agglomerate to form a monodisperse system, exhibiting a mean hydrodynamic diameter of 60.6nm±4.1nm, with a low average polydispersity index of 0.128±0.003, as required for intravenous applications. The system exhibits promising efficiency for magnetic hyperthermia, with a specific absorption rate of 14 W/g at a low field amplitude of 15.9kA/m and frequency of 62kHz. In a 50mg/mL density in 1mL, the temperature rises to 42.5°C in 1.9min.
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