Abstract
SummarySeveral bactericidal substances were isolated from the supernatant of murine monocytes incubated for 2 hours at 37°C in Eagle's medium in vitro with addition of 5. typhi (Ty2). Smaller quantities of the same substances were liberated from monocytes incubated without addition of bacteria. An in vivo protecting substance has also been isolated. This substance protected mice if injected at least 4 hours before the bacterial inoculum, and the protection lasted for about 10 days, but when administered simultaneously with bacteria or after onset of infection no protection could be achieved. The substance turned out to be a basic protein, labile to acid treatment and trypsin and stable to heating at 100°C for one hour.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
