Abstract

BackgroundSystemic inflammation relates to the initiation and progression of acute respiratory distress syndrome (ARDS). Neutrophil-to-lymphocyte ratio (NLR) and red blood cell distribution width (RDW)/albumin ratio have been reported to be predictive prognostic biomarkers in ARDS patients. However, the role of monocyte-to-lymphocyte ratio (MLR) as a prognostic inflammatory biomarker in a variety of diseases is rarely mentioned in ARDS. In this study, we explored the relationship between MLR and disease severity in ARDS patients and compared it with other indicators associated with 28-day mortality in patients with ARDS.MethodsWe retrospectively included 268 patients who fulfilled the Berlin definition of ARDS and were admitted to a single institute from 2016 to 2020. Clinical characteristics and experimental test data were collected from medical records within 24 h after the ARDS diagnosis. MLR, NLR, and RDW/albumin ratio levels were calculated. The primary clinical outcome was 28-day mortality. Logistic regression analysis was used to illustrate the relationship between indicators and 28-day mortality. Receiver operating characteristic (ROC) curve was used to evaluate the area under the curve (AUC), and propensity score matching (PSM) was employed to validate our findings.ResultsThe median MLR values were higher for non-survivors than for survivors before and after matching (P<0.001, P=0.001, respectively). MLR values were significantly associated with 28-day mortality (OR 2.956; 95% CI 1.873–4.665; P<0.001). MLR and NLR indicators were combined for predictive efficacy analysis, and its AUC reached 0.750. There was a significant increase in 28-day mortality depending on the increasing MLR level: low MLR group 38 (20.4%), high MLR group 47 (57.3%) (P<0.001).ConclusionsHigher MLR values were associated with 28-day mortality in patients with ARDS. Further investigation is required to verify this relationship with prospectively collected data.

Highlights

  • Acute respiratory distress syndrome (ARDS) is a noncardiogenic pulmonary edema induced by lung damage caused by inflammation, leading to fatal respiratory failure [1, 2]

  • The Acute Physiology and Chronic Health Evaluation II (APACHE II) score, Sequential Organ Failure Assessment (SOFA) score, and Simplified Acute Physiology Score (SAPS), which are used to assess the prognosis of critically ill patients, are not specific to acute respiratory distress syndrome (ARDS)

  • monocyte-to-lymphocyte ratio (MLR) and Neutrophil-to-lymphocyte ratio (NLR) indicators were combined for predictive efficacy analysis of 28-day mortality in ARDS patients, and its area under the curve (AUC) was 0.750 (Fig. 3 and Table 3)

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Summary

Introduction

Acute respiratory distress syndrome (ARDS) is a noncardiogenic pulmonary edema induced by lung damage caused by inflammation, leading to fatal respiratory failure [1, 2]. Despite recent advances in intensive care models [3, 4], mortality in ARDS patients remains high. Several studies have analyzed biomarkers in patients with ARDS, such as interleukin (IL)-1 beta, IL-6 [7], mucins with selectin ligands [8], and Th17/Treg ratio [9]. Those parameters cannot be detected immediately at bedside; most require special biological samples from patients and integration with other clinical data, which prolongs the diagnostic process. The role of monocyte-to-lymphocyte ratio (MLR) as a prognostic inflammatory biomarker in a variety of diseases is rarely mentioned in ARDS. We explored the relationship between MLR and disease severity in ARDS patients and compared it with other indicators associated with 28-day mortality in patients with ARDS

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