Monocyte to high-density lipoprotein cholesterol ratio as long-term prognostic marker in patients with coronary artery disease undergoing percutaneous coronary intervention

Ting-Ting Wu,Ying-Ying Zheng,Yi-Tong Ma,You Chen,Zi-Xiang Yu,Xiang Xie

doi:10.1186/s12944-019-1116-2

Abstract

BackgroundThe relation between monocyte to high-density lipoprotein cholesterol ratio (MHR) and coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI) remains controversial. The present study aims to assess the prognostic value of MHR in patients with CAD who underwent PCI.MethodsA total of 673 CAD patients were retrospectively enrolled and divided into four groups according to MHR values. Multivariate Cox regression analysis was performed to study the effects of different variables to clinical outcomes reported as major adverse cardiac events (MACE) and all-cause mortality (ACM).ResultsIn a multivariate Cox analysis, after adjustment of other confounders, MHR was found to be an independent predictor of ACM (HR: 3.655; 95% CI: 1.170–11.419, P = 0.026) and MACE (HR =2.390, 95% CI 1.379–4.143, p < 0.002). Having a MHR in the third and fourth quartile were associated with a 2.83-fold and 3.26 -flod increased risk of MACE.ConclusionsMHR is an independent predictor of ACM and MACE in CAD patients undergoing PCI.

Highlights

During the past three decades, percutaneous coronary intervention (PCI) has become one of the dominant methods for revascularization in patient with coronary artery disease (CAD)
We aimed to investigate the relationship between monocyte to high-density lipoprotein cholesterol ratio (MHR) and the clinical outcomes of CAD patients after PCI
In multivariate Cox proportional hazard regression analysis, MHR was found as an independent predictor of major adverse cardiac events (MACE) (HR =2.390, 95% confidence intervals (CIs) 1.379–4.143, p < 0.002), along with diabetes mellitus (HR = 1.911, 95% CI 1.241–2.941, p = 0.003), hypertension (HR = 1.576, 95% CI 1.011–2.455, p = 0.044), hemoglobin (HR = 0.980, 95% CI 0.965–0.995, p = 0.008) heart ratio (HR = 1.021, 95% CI 1.001–1.041, p = 0.042), low-density lipoprotein cholesterol (LDL-C)(HR:1.411; 95% CI: 1.178–1.690, P < 0.001), and Gensini score (HR = 1.006, 95% CI 1.001– 1.011, p = 0.029) were found as independent predictors of MACE

Summary

Introduction

During the past three decades, percutaneous coronary intervention (PCI) has become one of the dominant methods for revascularization in patient with coronary artery disease (CAD). Humoral biomarkers of inflammation are correlated with initiation, progression, Circulating monocytes as a source of various cytokines and molecules, interact with platelets and endothelial cells and leading to aggravation of inflammatory, prothrombotic pathways [4, 5]. Properties such as monocyte count to HDL-C ratio (MHR) could show the inflammatory status of a patient. The relation between monocyte to high-density lipoprotein cholesterol ratio (MHR) and coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI) remains controversial.

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