Monocyte-to-HDL-cholesterol ratio is associated with Ascending Aorta Dilatation in Patients with Bicuspid Aortic Valve.

Burak Acar,Sefa Unal,Serdar Mevlut Kuyumcu,Yasin Ozen,Ahmet Goktug Ertem,Mustafa Karanfil,Sinan Aydogdu,Ozcan Ozeke,Fatih Uçar,Cagrı Yayla,Mustafa Bilal Ozbay,Murat Gul

doi:10.4314/ahs.v21i1.14

Abstract

The importance of monocyte count-to-HDL-cholesterol ratio (MHR) in cardio- vascular diseases has been shown in various studies. Ascending aortic dilatation (AAD) is a common complication in the patients with bicuspid aortic valve. In this study, we aimed to investigate the relationship between MHR and the presence of aortic dilatation in the patients with bicuspid aortic valve. The study population included totally 347 patients with bicuspid aortic valve.169 patients with aortic dilatation (ascending aorta diameter ≥ 4.0 cm) and 178 patients with no aortic dilatation. Echocardiographic and laboratory measurement was done and compared between groups. The mean age of the participants was 44.7 ± 15.4 years and average ascending aorta diameter was 3.2 ± 0.3 cm in dilatation negative group and 4.4 ± 0.4 cm in positive group. MHR was significantly increased in in patients with aortic dilatation. MHR and uric acid level was independently associated with the presence of aortic dilatation in the patients with bicuspid aortic valve. We found a significant relationship between MHR and aortic dilatation in the patients with bicuspid aortic valve.

Highlights

One of the most common congenital cardiac malformation in clinical practice is bicuspid aortic valve (BAV)
Cite as: Acar B, Yayla C, Gul M, Karanfil M, Unal S, Uçar F, et al Monocyte-to-HDL-cholesterol ratio is associated with Ascending Aorta Dilatation in Patients with Bicuspid Aortic Valve
Monocytes and HDL-cholesterol are separately linked to degeneration pathophysiology of the bicuspid valve and there is a necessity to improve the present-day diagnosis and management of bicuspid valve illness, that's why we sought to identify the relation of admission monocyte count-to-HDL-cholesterol ratio (MHR) with the maximum diameter of the climbing aorta in bicuspid aortic valve patients

Summary

Introduction

One of the most common congenital cardiac malformation in clinical practice is bicuspid aortic valve (BAV). Some of the clinically important complications usually related to BAV are aortic valve dysfunction, aortic dissection, infective endocarditis, and ascending aorta dilatation (AAD)[1]. The importance of monocyte count-to-HDL-cholesterol ratio (MHR) in cardio- vascular diseases has been shown in various studies. Ascending aortic dilatation (AAD) is a common complication in the patients with bicuspid aortic valve. We aimed to investigate the relationship between MHR and the presence of aortic dilatation in the patients with bicuspid aortic valve. MHR and uric acid level was independently associated with the presence of aortic dilatation in the patients with bicuspid aortic valve.

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