Abstract
Background: Monocyte count and serum albumin (Alb) have been proven to be involved in the process of systemic inflammation. Therefore, we investigated the prognostic value of monocyte-to-albumin ratio (MAR) in patients who underwent percutaneous coronary intervention (PCI).Methods: We enrolled a total of 3561 patients in the present study from January 2013 to December 2017. They were divided into two groups according to MAR cut-off value (MAR < 0.014, n=2220; MAR ≥ 0.014, n=1119) as evaluated by receiver operating characteristic (ROC) curve. The average follow-up time was 37.59 ± 22.24 months.Results: The two groups differed significantly in the incidences of all-cause mortality (ACM; P<0.001), cardiac mortality (CM; P<0.001), major adverse cardiovascular events (MACEs; P=0.038), and major adverse cardiovascular and cerebrovascular events (MACCEs; P=0.037). Multivariate Cox regression analyses revealed MAR as an independent prognostic factor for ACM and CM. The incidence of ACM increased by 56.5% (hazard ratio [HR] = 1.565; 95% confidence interval [CI], 1.086–2.256; P=0.016) and that of CM increased by 76.3% (HR = 1.763; 95% CI, 1.106–2.810; P=0.017) in patients in the higher-MAR group. Kaplan–Meier survival analysis suggested that patients with higher MAR tended to have an increased accumulated risk of ACM (Log-rank P<0.001) and CM (Log-rank P<0.001).Conclusion: The findings of the present study suggested that MAR was a novel independent predictor of long-term mortality in patients who underwent PCI.
Highlights
Despite advances in prevention, diagnosis, and treatment of cardiovascular disease over the past two decades, it is still the leading cause of deaths in both developed and developing countries, and coronary artery disease (CAD) makes the greatest contribution to CVD [1]
The incidence of all-cause mortality (ACM) increased by 56.5% and that of cardiac mortality (CM) increased by 76.3% (HR = 1.763; 95% confidence interval (CI), 1.106–2.810; P=0.017) in patients in the higher-monocyte-to-albumin ratio (MAR) group
In acute coronary syndrome (ACS) patients, we found that age, sex, smoking, monocyte count, Alb level, Cr, uric acid (UA), high-density lipoprotein cholesterol (HDL-C), and use of statin and aspirin were significantly different between the groups
Summary
Diagnosis, and treatment of cardiovascular disease over the past two decades, it is still the leading cause of deaths in both developed and developing countries, and coronary artery disease (CAD) makes the greatest contribution to CVD [1]. Monocytes are innate immunity’s primary players and comprise 10% of human blood leukocytes [5]. They remain in a steady state in blood vessels and transmigrate across endothelium into the vascular intima when stimulated by inflammatory cytokines. We investigated the prognostic value of monocyte-to-albumin ratio (MAR) in patients who underwent percutaneous coronary intervention (PCI). Methods: We enrolled a total of 3561 patients in the present study from January 2013 to December 2017. They were divided into two groups according to MAR cut-off value (MAR < 0.014, n=2220; MAR ≥ 0.014, n=1119) as evaluated by receiver operating characteristic (ROC) curve.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
