Abstract
Monocyte distribution has recently emerged as a promising biomarker of sepsis, especially in acute setting, such as Emergency Department and Intensive Care Unit. This study aimed to evaluate the accuracy of monocyte distribution width (MDW) for early detecting patients with sepsis by performing a systemic review and meta-analysis of published studies. Relevant publications were identified by a systematic literature search on PubMed and Google Scholar from inception to September 07, 2021. Studies were divided into two groups based on the sepsis criteria applied, namely sepsis-2 or sepsis-3. Ten studies including 9,475 individuals, of whom 1,370 with sepsis (742 according Sepsis-2 and 628 according to Sepsis-3), met the inclusion criteria for our meta-analysis. The pooled sensitivity and specificity were 0.789 and 0.777 for Sepsis-2 criteria, 0.838 and 0.704 for Sepsis-3 criteria. MDW represents a reliable biomarker for sepsis screening.
Highlights
Sepsis represents an important health burden worldwide
monocyte distribution width (MDW) represents a reliable biomarker for sepsis screening
All studies investigating the diagnostic efficacy of MDW for sepsis were searched for inclusion
Summary
Sepsis represents an important health burden worldwide. Recognition is fundamental for promptly starting the appropriate treatment in order to improve the patient’s outcome and to reduce mortality. The diagnosis of sepsis, which relies on the integration of clinical and laboratory findings, is still challenging. Sepsis is characterised by no specific signs and symptoms. Blood culture, which represents the gold standard for sepsis diagnosis, has several drawbacks, including a long turnaround time and a high rate of false-negative findings (up to 70%) [1]. Many efforts are ongoing for identifying a reliable biomarker to early recognize patients at high risk of sepsis
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