Abstract
In rheumatological practice monoclonal gammopathy of undetermined significance (MGUS) is acommon incidental finding. Several rheumatic inflammatory diseases are known to have an elevated risk of MGUS, which can evolve into multiple myeloma or other lymphatic malignancies. The relevant definitions of disease entities are described, as well as algorithms for further diagnostic work-up and follow-up for monoclonal gammopathy, depending on the risk of progression. Therapeutic strategies against multiple myeloma are presented. Some of these therapeutic modalities could play afuture role in treating plasma cell-dominated autoimmune diseases.
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