Abstract
Background: We assessed the prevalence and isotype distribution of monoclonal gammopathy in the Noor Pathobiology laboratory of Iran. Patients and Methods: From June 21, 2012 to June22, 2014, a total number of 18489 Iranian patients who referred to Noor Pathobiology lab were included in our study. Serum protein electrophoresis was performed on all sera. Serum sample with discrete or localized band was subjected to capillary zone electrophoresis (CZE) and immuno subtraction by Capillaries 2 instrument. Sex- and age-related prevalence rates of monoclonal gammopathy were calculated. Results: Monoclonal gammopathy was detected in 736 of the 18489 study participants, yielding a prevalence of 3.98% in the total population screened. The prevalence in men was higher than in women. 197 samples of 736 samples were immuno typed. Isotype distribution of immuno globulins were IgG/Kappa in 33.5% (n=66) of patients, IgG/Lambda in 16.7% (n=33), IgA/Kappa in 23.3% (n=46), IgA/Lambda in 7.6% (n=15), IgM/Kappa in 7.6% (n=15), IgM/Lambda in 1% (n=2), Kappa light chain in 3.5% (n=7), Lambda light chain in 2% (n=4) and Biclonal in 4.5% (n=9). Conclusion: Among patients referred to our clinical lab, monoclonal gammopathy was found in 3.98 percent of persons. IgG was the most frequently found Ig class (50.2%), followed by IgA (30.9%).Our findings can be the basis of future screening programs and preventive strategies.
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