Abstract
Intercalated duct cells and ductal basal cells in the salivary glands were suggested to be probable progenitor cells of salivary gland tumors. Different monoclonal anti-keratin antibodies (KL1, PKK1, PKK2, PKK3, RGE53, K4.62, K8.12, K8.13, K8.60, RPN1160, RPN1161, RPN1162, RPN1163, RPN1164, RPN1165, RPN1166) and polyclonal anti-keratin antiserum (TK) were tested on paraffin sections of Carnoy's- and formalin-fixed normal salivary gland tissues (parotid and submandibular glands). Monoclonal keratin antibodies could detect nos. 1, 5, 6, 7, 8, 10, 11, 13, 16, 17, 18, and 19 keratins. Intercalated duct cells of normal salivary glands displayed positive staining with monoclonal antibodies KL1, K4.62, K8.12, K8.13, K8.60, RPN1160, and RPN1164. Ductal basal cells revealed positive staining with PKK1 (nos. 19 or 18, 8) (Carnoy's fixed section), and K8.12 (nos. 16, 13), K4.62 (no. 19), RPN1165 (no. 19) keratins, which bind to nos. 19, 18, 16, 13, 8. Intercalated duct cells contained wide spectrum keratins. Keratin stainings (nos. 19 or 16, 13) of ductal basal cells in formalin fixed sections suggested nos. 19, 16, 13 proteins to be some marker for progenitor cells of salivary gland tumors.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
